Repair and regeneration of the injured cord tissue.
Improves the quality of life
Improve in the sensory and motor function.
Protocol Outline for Spinal Cord Injury:-
Exact protocol is based after evaluation of the complete case study
“Bone marrow-derived stem cells concentrate (BMSCs)” via laminectomy/Intrathecally because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels
1) To modulate the regeneration process
2) Recruit bone marrow progenitor cells to loci of injury
3) Provides adhesion site for stem cells
4) Platelets fibrin provides migration highway at the site of injury
We infuse autologous bone marrow derived cultured mesenchymal stem cells via intrathecally because MSCs is the multipotent cells which is able to differentiate into neuron cells and also provide new cells for the repair and remodeling of damaged tissues in the brain.
Umbilical cord tissue derived cultured Mesenchymal stem cells (UCMSCs) is immature, non immune surface marker cells and also have better regeneration capacity.
We also transplant Umbilical cord tissue derived Mesenchymal stem cells (UCMSCs) in the combination with BMSCs because BMSCs (or in presence of HSCs) provide enhanced environment for MSCs activation.
Spinal Cord Injury Rehabilitation:-
Physiotherapy is one of the part of stem cell therapy. Both paraplegics and quadriplegics should have some kind of physiotherapy to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation and physiotherapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.
Follow-up with patients:-
Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year intervals.
Sykova et al. 2006 (Cell Transplantation). Autologous Bone Marrow Transplantation in Patients with Subacute and Chronic Spinal Cord Injury.
Geffner et al. 2008 (Cell Transplantation). Administration of Autologous Bone Marrow Stem Cells Into Spinal Cord Injury Patients Via Multiple Routes Is Safe and Improves Their Quality of Life: Comprehensive Case Studies.