Spinal Cord Injury

Stem cell therapy for Spinal Cord Injury

A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. . Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy axons – extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. Spinal cord injury effects vary according to the type and level of spinal cord injury, and can be sorted into two main types: Complete and Incomplete Spinal Cord Injury

Complete spinal cord injury, there is no function below the “neurological” level, defined as the lowest level that has intact neurological function. If a person has some spinal injury level below which there is no motor and sensory function, the injury is said to be a complete spinal cord injury.

Incomplete spinal cord injury will retain some sensation or movement below the level of spinal cord injury. Incomplete spinal cord injuries may recover some walking ability. In addition to a loss of sensation and motor function below the point of spinal cord injury, individuals with spinal cord injuries will often experience other complications of spinal cord injury.

Stem Cell Services for Spinal Cord Injury (SCI)

The present standard of care for SCI is methylprednisolone and/or decompression but they have only marginal benefits. Many experimental studies have suggested that the transplantation of bone marrow stem cells (BMSCs) promote functional improvements after SCI because bone marrow derived mesenchymal stem cells (MSCs) have the capacity to differentiated into neurons (oligodendrites, astrocytes) and glial cells after injecting at the injury site.

The implantation of autologous bone marrow stem cells (BMSCs) is safe and no reporting of complication or adverse effects. For obtaining a high local stem cell concentration at the injured site, we use a new route of transplantation by combining both via Intrathecally and via Laminectomy(injecting the cells at multiple sites into the injured area) so that bone marrow stem cells can reach at the necessary target to fulfill their niche and promote the endogenous repair with better results in acute and chronic stages also.

Our Objective

Improve in the sensory and motor function.
Repair and regeneration of the injured cord tissue.
Improves the quality of life

Protocol Outline for Spinal Cord Injury:-

Exact protocol is based after evaluation of the complete case study

We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via laminectomy/Intrathecally because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-

Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.

Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.

Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels

Platelets: –

1) To modulate the regeneration process
2) Recruit bone marrow progenitor cells to loci of injury
3) Provides adhesion site for stem cells
4) Platelets fibrin provides migration highway at the site of injury
We infuse autologous bone marrow derived cultured mesenchymal stem cells via intrathecally because MSCs is the multipotent cells which is able to differentiate into neuron cells and also provide new cells for the repair and remodeling of damaged tissues in the brain.
Umbilical cord tissue derived cultured Mesenchymal stem cells (UCMSCs) is immature, non immune surface marker cells and also have better regeneration capacity.
We also transplant Umbilical cord tissue derived Mesenchymal stem cells (UCMSCs) in the combination with BMSCs because BMSCs (or in presence of HSCs) provide enhanced environment for MSCs activation.

Spinal Cord Injury Rehabilitation:-

Physiotherapy is one of the part of stem cell therapy. Both paraplegics and quadriplegics should have some kind of physiotherapy to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation and physiotherapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year intervals.

Scientific Papers:-

Geffner et al. 2008 (Cell Transplantation). Administration of Autologous Bone Marrow Stem Cells Into Spinal Cord Injury Patients Via Multiple Routes Is Safe and Improves Their Quality of Life: Comprehensive Case Studies.
Sykova et al. 2006 (Cell Transplantation). Autologous Bone Marrow Transplantation in Patients with Subacute and Chronic Spinal Cord Injury.

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