PROTOCOL OUTLINES FOR “RETINITIS PIGMENTOSA” TREATMENT:-
Exact protocol is based after evaluation of complete case study 1. We refer to transplant autologous bone marrow derived stem cell concentrate (BMSCs) via intravitreous and retrobulbar
“Bone marrow-derived stem cells concentrate (BMSCs)” provide a rich growth factor environment that may enhance the new blood vessel formation and contains all types of regenerative cells including:-
Mesenchymal Stem Cells (MSCs):- MSCs which differentiate into many types of cells such as Neuron, bone, cartilage, muscle and so more and also provide immune regulatory property.
Hematopoietic Stem Cells (HSCs):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
Endothelial Stem Cells (ESCs):- ESCs which differentiate into all types of blood vessels.
1) To modulate the regeneration process
2) Recruit bone marrow progenitor cells to loci of injury
3) Provide adhesion site for stem cells
4) Platelets fibrin provides migration highway at the site of injury
We provide 3-4 different doses of stem cells at some specific interval to get more recovery for retinitis pigmentosa treatment.
We also start stem cell supplement (Stem-Kine) during and after stem cell transplantation to get better improvement.
We also transplant cultured mesenchymal stem cells (isolated from bone marrow or cord tissue) to fulfill the requirement of MSCs cell dose because the cell dose of MSCs is low in bone marrow concentrate.
Follow-up with patients:-
Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor all the evaluation.
Dahlmann-Noor et al.2010 (Can J Opthalmol). Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve
Smith et al. 2004 (The Journal of Clinical Investigation). Bone marrow–derived stem cells preserve cone vision in retinitis pigmentosa.