Retinitis Pigmentosa

Stem cell therapy for Retinitis Pigmentosa

Retinitis pigmentosa (RP) is a heritable group of blinding diseases characterized by progressive peripheral vision loss and night vision difficulties. RP constitutes abnormalities in photoreceptor cells (rods and cones) and retinal pigment epithelium (RPE) dystrophies caused by molecular defects in more than 40 different genes.

RP can be passed on by all types of inheritance: approximately 20% of RP is autosomal dominant (ADRP), 20% is autosomal recessive (ARRP), and 10% is X linked (XLRP), while the remaining 50% is found in patients without any known affected relatives.

Stem Cell Therapy for Retinitis Pigmentosa (RP):-

Currently no definitive treatment for retinitis pigmentosa exists because it is a progressive disease that damage photoreceptors cells (rods and cones) or the retinal pigment epithelium (RPE) of the retina. Scientifically proved that stem cell transplantation via “retrobulbar and intravitreous” may prevent further loss of photoreceptor cells and retinal pigment epithelial cells (RPE) and can regenerate photoreceptor cells and RPE cells (Smith et al. 2004).

Stem cell transplantation for “retinitis pigmentosa” treatment provides some major advantages are as follow:-

Regenerate Retinal Pigment Epithelial cells
Regenerate of photoreceptor cells
Provides revascularization
Activate resident stem cells


Exact protocol is based after evaluation of complete case study 1. We refer to transplant autologous bone marrow derived stem cell concentrate (BMSCs) via intravitreous and retrobulbar

“Bone marrow-derived stem cells concentrate (BMSCs)” provide a rich growth factor environment that may enhance the new blood vessel formation and contains all types of regenerative cells including:-

Mesenchymal Stem Cells (MSCs):- MSCs which differentiate into many types of cells such as Neuron, bone, cartilage, muscle and so more and also provide immune regulatory property.

Hematopoietic Stem Cells (HSCs):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.

Endothelial Stem Cells (ESCs):- ESCs which differentiate into all types of blood vessels.

Platelets: –

1) To modulate the regeneration process
2) Recruit bone marrow progenitor cells to loci of injury
3) Provide adhesion site for stem cells
4) Platelets fibrin provides migration highway at the site of injury

We also transplant cultured mesenchymal stem cells (isolated from bone marrow or cord tissue) to fulfill the requirement of MSCs cell dose because the cell dose of MSCs is low in bone marrow concentrate.
We provide 3-4 different doses of stem cells at some specific interval to get more recovery for retinitis pigmentosa treatment.
We also start stem cell supplement (Stem-Kine) during and after stem cell transplantation to get better improvement.

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor all the evaluation.

Scientific Articles:-

Smith et al. 2004 (The Journal of Clinical Investigation). Bone marrow–derived stem cells preserve cone vision in retinitis pigmentosa.
Dahlmann-Noor et al.2010 (Can J Opthalmol). Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve

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