Peripheral Arterial Disease

Stem cell therapy for Peripheral Arterial Disease

Peripheral arterial disease (PAD) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood. Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.

Peripheral arterial disease (PAD), causing an inadequate oxygen supply to the limbs. Mainly the risk factors of peripheral vascular disease are nicotine use, diabetes mellitus, hypertension and hypercholesterolemia. Based on the severity of the symptoms, usually two clinical presentations are distinguished: intermittent claudication (IC) is characterized by pain upon walking which is the most common presenting symptom while critical limb ischemia (CLI) is a more severe form in which pain occurs at rest and which is accompanied by necrosis and ulceration and patients with CLI are also at high risk for limb amputation.

Stem cell Treatment for Peripheral Arterial Disease(PAD):-

Currently available surgical or endovascular revascularization treatment cannot be done in those patients who could not have arterial bypass graft surgery due to poor run-off or poor general medical condition. There may be some side effect by using the conventional method for peripheral arterial disease.

Bone Marrow derived Stem cells transplantation via intra-muscular and intra-arterial (by using with balloon catheter) provide neoangiogenesis (new vessel formation) in ischemic tissue. It is the only most effective treatment option for Critical Limb Ischaemia patients (severe peripheral arterial disease) and to reduce the major amputation. For obtaining a high local stem cell concentration in the ischemic leg, we use a new route of transplantation by combining both intra-arterial (by using with balloon catheter) and intra-muscular injections so that high concentration of stem cells can reach into all ischemic muscles. Bone Marrow Mononuclear cells (BM-MNC or BM stem cells concentrate) is more useful in peripheral arterial disease to get more re-vascularization because it contains all needed regenerative cells and the hematopoietic stem cells (HSCs) in the BM-MNC release angiogenic growth factors such as vascular endothelial growth factor (VEGF) which improves endothelium-dependent vasodilation in patients with peripheral arterial disease. Autologous BM-MNC implantation improves ankle-brachial index (ABI) measurements, SaO2 relief of rest pain, and ulcer healing and also to reduce major amputations.

Our Objective:

  1. To improve revascularization in atherosclerotic artery
  2. Increase pain free walking time
  3. Reduce the risk of amputation rates
  4. Improve the Ulcer/Gangrene healing

Protocol Outline for Peripheral Arterial Disease Treatment:

1. We transplant autologous bone marrow derived stem cell concentrate (BMSCs) via both intra-muscular and intra-arterial (by using with balloon catheter).

2. “Bone marrow-derived stem cells concentrate (BMSCs)” provide a rich growth factor environment that may enhance the new blood vessel formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells needed including:-

Mesenchymal Stem Cells (MSCs):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron, muscle and so more.

Hematopoietic Stem Cells (HSCs):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation. Hematopoietic stem cells (HSCs) in the BM-MNC also release angiogenic growth factors such as vascular endothelial growth factor (VEGF) which improves endothelium-dependent vascularization in patients with peripheral arterial disease.

Endothelial Stem Cells (ESCs):- ESCs which differentiate into all types of blood vessels.

Platelets: -

  1. To modulate the regeneration process
  2. Recruit bone marrow progenitor cells to loci of injury
  3. Provides adhesion site for stem cells
  4. Platelets fibrin provides migration highway at the site of injury

3. We also start stem cell supplement (Stem-Kine) during and after stem cell transplantation to get better improvement.

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor resting ankle-brachial pressure index (ABI), arterial oxygen saturation (SaO2), pain-free walking time and rest pain scale evaluation.

Scientific Articles:-

1. T. Bartsch et al. 2007 (Clinical Research in Cardiology). Transplantation of Autologous mononuclear bone marrow stem cells in patients with peripheral arterial disease (TAM-PAD study).

2. Hernandez et al. 2007 (Atherosclerosis). Autologous bone-marrow mononuclear cell implantation in patients with severe lower limb ischaemia: A comparison of using blood cell separator and Ficoll density gradient centrifugation.

If you have any queries related to stem cell therapy for Peripheral Arterial Disease then contact us without any hesitation on our contact numbers:-
Mb. No: +91-9891818024 , 9650699988
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