Stem Cell Therapy for Optic Nerve Damage:-
Vision lost due to optic nerve atrophy cannot be recovered if the cause can be found earlier; further vision loss and blindness may be prevented. Currently there is no treatment option for optic nerve damage patients but after many clinical and experimental studies it has been proved that stem cells transplantation via “retrobulbar and intravitreous” can again regenerate retinal ganglion cells and their axons in the optic nerve.
Stem Cell Therapy for “eye related disorder” provides some major advantages are as follow:-
These all are the techniques which have discussed above useful only for small cartilage defect and not suitable for major cartilage defect because they form fibrocartilge which is not rigid to support complete weight
Regenerate Retinal Pigment Epithelial cells
Regenerate of photoreceptor cells
Neuroprotection and Neuroregeneration
PROTOCOL OUTLINES FOR “OPTIC NERVE DAMAGE” TREATMENT:
Exact protocol is based after evaluation of complete case study
We refer to transplant autologous bone marrow derived stem cell concentrate (BMSCs) via intravitreous and retrobulbar
“Bone marrow-derived stem cells concentrate (BMSCs)”
provide a rich growth factor environment that may enhance the new blood vessel formation and contains all types of regenerative cells including:-
Mesenchymal Stem Cells (MSCs):- MSCs which differentiate into many types of cells such as Neuron, bone, cartilage, muscle and so more and also provide immune regulatory property.
Hematopoietic Stem Cells (HSCs):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
Endothelial Stem Cells (ESCs):- ESCs which differentiate into all types of blood vessels.
Recruit bone marrow progenitor cells to loci of injury
Provide adhesion site for stem cells
Platelets fibrin provides migration highway at the site of injury
We also transplant cultured mesenchymal stem cells (isolated from bone marrow and cord tissue) to fulfill the requirement of MSCs cell dose because the cell dose of MSCs is low in bone marrow concentrate.
We provide 3-4 different doses of stem cells at some specific interval to make the treatment better for optic nerve damage treatment.
To modulate the regeneration process
Follow-up with patients:-
Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 month intervals to monitor all the evaluation.
Quigley et al. 2004 (Nature Publishing Group). Stem Cells to replace the optic nerve.