Muscular Dystrophy

Stem cell therapy for Muscular Dystrophy

WHAT IS Muscular Dystrophy (MD)

Duchenne muscular dystrophy (DMD) is general term for a number of hereditary, progressive degenerative disorders affecting skeletal muscles, and often other organ systems whose manifestation is augmented by inflammatory mechanisms. Given this modality appears to function via suppression of underlying inflammation.

There are many different types of muscular dystrophy : -

  1. Becker muscular dystrophy
  2. Duchenne muscular dystrophy
  3. Emery-Dreifuss muscular dystrophy
  4. Facioscapulohumeral muscular dystrophy
  5. Limb-girdle muscular dystrophy
  6. Myotonia congenita
  7. Myotonic dystrophy

STEM CELL SERVICES FOR Muscular Dystrophy (MD) : -

There is no cure for Muscular Dystrophy but stem cell therapy mainly focuses on the inflammatory response in Muscular Dystrophy as a target for mesenchymal stem cell (MSC) therapy. In contrast to other cell based therapies attempted in DMD, Mesenchymal Stem Cells have the advantages to treat Muscular Dystrophy:-

  1. ability to fuse with and genetically complement dystrophic muscle to regenerate and repair the dystrophic muscle
  2. produce anti-inflammatory activities to stop the inflammation in MD
  3. produce trophic factors that may augment activity of endogenous repair cells.

Protocol Outline for Muscular Dystrophy:-

  1. We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via intrathecally/intravenously because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
    • Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
    • Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
    • Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels.
    • Platelets: -
      1. To modulate the regeneration process
      2. Recruit bone marrow progenitor cells to loci of injury
      3. Provides adhesion site for stem cells
      4. Platelets fibrin provides migration highway at the site of injury
  2. We also transplant cultured mesenchymal stem cells (isolated from bone marrow and cord tissue) to fulfill the requirement of MSCs cell dose because the cell dose of MSCs is low in bone marrow concentrate.

Muscular Dystrophy Rehabilitation:-

Rehabilitation is the part of stem cell therapy. Muscular Dystrophy patients should have some kind of rehabilitation to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation including physiotherapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.

Key Points:-

  1. Physical therapy may improve your ability to perform daily activities and make you feel better.
  2. Occupational therapy may help you perform daily activities more easily-especially those involving your hands and arms, such as grooming, dressing, and eating. Assistive devices may be used to help you perform daily tasks.

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year interval.

Scientific Articles:-
1. Thomas et al. 2009 (Cell Immunology). Mesenchymal Stem Cells as Anti-inflammatories: Implications for Treatment of Duchenne Muscular Dystrophy.
2. Helen et al. 2008 (The New England Journal of Medicine). Cell Therapy for Muscular Dystrophy.

If you have any queries related to stem cell therapy for Muscular Dystrophy then contact us without any hesitation on our contact numbers:-
Mb. No: +91-9891818024 , 9650699988
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