Protocol Outline for Motor Neuron Diseases:-
Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels.
1) To modulate the regeneration process
2) Recruit bone marrow progenitor cells to loci of injury
3) Provides adhesion site for stem cells
4) Platelets fibrin provides migration highway at the site of injury
We transplant cultured mesenchymal stem cells (MSCs) isolated from bone marrow or cord tissue after evaluation of complete case study because MSCs is the multipotent cells which is able to differentiate into neuron cells and stop further progression of motor neuron disease.
We perform 3 times stem cell infusion via intreathecally and intravenously in “Motor Neuron Disease” patients.
We also start stem cell supplement (Stem-Kine) during and after stem cell transplantation to get better improvement.
We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via intrathecally/intravenously because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
Motor Neuron Diseases (MSDs) Rehabilitation:-
Rehabilitation is the part of stem cell therapy. MSDs patients should have some kind of rehabilitation included therapy to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation included physical therapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.
Rehabilitation-including physical therapy, occupational therapy, speech therapy, and cognitive retraining-may help reduce these MNDs disabilities.
Occupational therapy may help you perform daily activities more easily-especially those involving your hands and arms, such as grooming, dressing, and eating. Assistive devices may be used to help you perform daily tasks.
Speech therapy may improve your communication skills if MNDs symptoms are making speaking difficult.
Cognitive retraining may help improve cognitive impairment caused by MNDs
Physical therapy may improve your ability to perform daily activities and make you feel better.
Follow-up with patients:-
Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year interval.