Motor Neuron Diseases like ALS, PLS

Stem cell therapy for Motor Neuron Disease

The motor neuron diseases (MNDs) are a group of progressive neurological disorders that destroy nerve cells. Normally, messages from nerve cells in the brain (called upper motor neurons) are transmitted to nerve cells in the brain stem and spinal cord (called lower motor neurons) and from them to particular muscles that selectively affect motor neurons, the cells that control voluntary muscle activity including speaking, walking, breathing, swallowing and general movement of the body.

There are different forms of motor neuron diseases (MNDs)

  1. ALS (amyotrophic lateral sclerosis) also called Lou Gehrig's which affects both upper and lower motor neurons. ALS is the most common form and accounts for approx. 60% to 70% of all cases.
  2. PBP (progressive bulbar palsy) which affects the lower motor neurons of the brain stem, causing slurred speech and difficulty chewing and swallowing. PBP accounts for about 20% of all cases
  3. PMA (progressive muscular atrophy) which affects only lower motor neurons in the spinal cord. PMA accounts for the remaining 10% of cases.
  4. PLS (primary lateral sclerosis) which affects only lower motor neurons. PLS is a very rare form of MND. PLS, unlike the other forms, is not fatal. In some very rare cases, patients with PLS eventually have ALS

Stem cell Services for Motor Neuron Diseases (MNDs):-

There is no standard treatment for the MNDs. The drug “Riluzole” and some others are thought to extend the lifespan of an ALS patient by only a few months. There are less effective medications to slow the progression of Motor neuron diseases that’s why patients with MNDs cannot be medically cured. Stem cell is the only option which has some improvements in MNDs patients. Treatment with autologous bone marrow derived Mesenchymal stem cells (MSCs) provide multiple mechanisms including neuroprotection, immunomodulation and neuroregeneration in MSDs patients after intrathecally/intravenously transplantation. Mesenchymal stem cells (MSCs) has the property to differentiate into damaged neuron and regenerate damaged neuron.

Protocol Outline for Motor Neuron Diseases:-

  1. We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via intrathecally/intravenously because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
    • Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
    • Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
    • Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels.
    • Platelets: -
      1. To modulate the regeneration process
      2. Recruit bone marrow progenitor cells to loci of injury
      3. Provides adhesion site for stem cells
      4. Platelets fibrin provides migration highway at the site of injury
  2. We transplant cultured mesenchymal stem cells (MSCs) isolated from bone marrow or cord tissue after evaluation of complete case study because MSCs is the multipotent cells which is able to differentiate into neuron cells and stop further progression of motor neuron disease.
  3. We perform 3 times stem cell infusion via intreathecally and intravenously in “Motor Neuron Disease” patients.
  4. We also start stem cell supplement (Stem-Kine) during and after stem cell transplantation to get better improvement.

Motor Neuron Diseases (MSDs) Rehabilitation:-

Rehabilitation is the part of stem cell therapy. MSDs patients should have some kind of rehabilitation included therapy to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation included physical therapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.

Rehabilitation-including physical therapy, occupational therapy, speech therapy, and cognitive retraining-may help reduce these MNDs disabilities.

Key Points:-

  1. Physical therapy may improve your ability to perform daily activities and make you feel better.
  2. Occupational therapy may help you perform daily activities more easily-especially those involving your hands and arms, such as grooming, dressing, and eating. Assistive devices may be used to help you perform daily tasks.
  3. Speech therapy may improve your communication skills if MNDs symptoms are making speaking difficult.
  4. Cognitive retraining may help improve cognitive impairment caused by MNDs

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year interval.

If you have any queries related to stem cell therapy for Motor Neuron Disease then contact us without any hesitation on our contact numbers:-
Mb. No: +91-9891818024 , 9650699988
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