Liver Disease

Stem cell therapy for Liver Disease

Overview

Liver disease is any condition that causes liver inflammation or tissue damage and affects liver function. The liver is a vital organ located in the upper right-hand side of the abdomen. It is as large as a football, weighs 2-3 pounds, and performs numerous functions for the body: converting nutrients derived from food into essential blood components, storing vitamins and minerals, regulating bloods clotting, producing proteins and enzymes, maintaining hormone balances, and metabolizing and detoxifying substances that would otherwise be harmful to the body. The liver makes factors that help the human immune system fight infection, removes bacteria from the blood, and makes bile, which is essential for digestion.

What is liver disease?

Liver disease is categorized both by the cause and the effect it has on the liver. Causes may include infection, injury, exposure to drugs or toxic compounds, an autoimmune process, or a genetic defect that leads to the deposition and build-up of damaging substances such as iron or copper. Effects may include inflammation, scarring, obstructions, clotting abnormalities, and liver failure.

Other Treatments FOR Liver disease:-

Although liver has a very good regenerative capacity but in chronic liver damage, this begins to fail, and then fibrosis, and eventually cirrhosis develops, called end stage liver disease (ESLD). Chronic liver disease is the fifth leading cause of death after cancer, cardiovascular disease, stroke, and respiratory disease.

At present liver transplantation is the only therapeutic option for patients with acute and chronic ESLDs and liver based metabolic defects. Liver transplantation, however, has the disadvantage of requiring lifelong immunosuppressant, with 10–15% of patients dying whilst on the waiting list due to the shortage of donated organs.

Hepatocyte Cells transplantation has been suggested as an alternative to liver transplantation, especially for hepatic disorders but the widespread application of hepatocyte transplantation, however, is also limited by organ availability, by problems with viability of isolated hepatocytes after cryopreservation, and by the potential formation of hepatocyte aggregates after transplantation because hepatocyte cell has the problems of insufficient cell survival and engraftment.

Stem Cell therapy FOR Liver disease:-

A lot of clinical trials have shown that Stem cell therapy is successful in liver related disorder like acute liver failure or end stage liver disease (ESLDs). So the concept is that stem cell has the potential to diffrentiated into hepatocyte cells after transplantation in liver disease and show improvement for all the evaluations in liver related disorder.

Stem Cell Transplantation:-

For obtaining a high local stem cell concentration at the injured site, we use a new route of transplantation by combining three ways:-

  1. Intra portal vein
  2. Hepatic artery
  3. via Intrvenously

So by using the combining methods, Stem cells reaches at the necessary target to fulfill their niche and promote the endogenous repair with better results in acute and chronic stages also. Stem Cell therapy offers the potential benefits when transplanted into liver disease.

1. Stem cell can differentiate or regenerate into hepatocyte cells so recover the damaged hepatocytes cells in the liver cirrhosis.

2. Stem cell transplant also provide new vascularization so it provides good environment for the renewal, differentiation of stem cells into hepatocytes.

3. Stem cell provides immune-regulatory properties by secreting anti-inflammatory cytokines so stop inflammation and slow down or stop further deterioration of hepatocytes cells.

Protocol Outline for Liver Disease:-

  1. We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via intrathecally/intravenously because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
    • Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
    • Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
    • Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels.
    • Platelets: -
      1. To modulate the regeneration process
      2. Recruit bone marrow progenitor cells to loci of injury
      3. Provides adhesion site for stem cells
      4. Platelets fibrin provides migration highway at the site of injury

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year interval.

Scientific Articles:-
1. Salama et al. 2010 (Cell Transplant). Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases.
2. Khan et al. 2008 (Transplant Proc). Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure: a preliminary study.

If you have any queries related to stem cell therapy for Liver Disease then contact us without any hesitation on our contact numbers:-
Mb. No: +91-9891818024 , 9650699988
To get quick response, fill our quick contact form……

POST YOUR QUERY
Name Phone Number Email Address Comment