Cornonary Arterial Disease

Stem cell therapy for Cornonary Arterial Disease

Coronary arterial disease (CAD) is a condition in which plaque builds up inside the coronary arteries that supply oxygen-rich blood to your heart muscle. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood. Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body. The patients with coronary arterial disease also experience angina.

Coronary arterial disease (PAD) causing an inadequate oxygen supply to the heart. Mainly the risk factors of coronary vascular disease are nicotine use, diabetes mellitus, hypertension and hypercholesterolemia.

Stem cell services for Cornonary Arterial Disease

Currently available surgical or endovascular revascularization like angioplasty and coronary artery bypass graft (CABG) are the main treatments for coronary arterial disease and myocardial infarction. Coronary artery disease involves not only the blockage of major arteries, but also the death of small blood vessels or capillaries and heart muscle. But the stem cells transplant with angioplasty induces the neo-vascularization and also reduces frequency of angina episodes.

Transplantation of Bone Marrow Stem Cells into the infarct-related coronary artery via an angioplasty (by using with balloon catheter) provides neoangiogenesis (new vessel formation) in ischemic coronary artery. Bone Marrow Mononuclear cells (BM-MNC or Bone Marrow stem cells concentrate) is more useful in coronary arterial disease to get more re-vascularization because it contains all needed regenerative cells and also containing angiogenic growth factors such as vascular endothelial growth factor (VEGF) which improves endothelium-dependent vasodilation in patients with coronary arterial disease.

Protocol Outline for Cerebral Palsy:-

  1. We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via intrathecally/intravenously because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
    • Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
    • Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
    • Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels.
    • Platelets: -
      1. To modulate the regeneration process
      2. Recruit bone marrow progenitor cells to loci of injury
      3. Provides adhesion site for stem cells
      4. Platelets fibrin provides migration highway at the site of injury
  2. We also transplant cultured mesenchymal stem cells (MSCs) isolated from bone marrow or cord tissue after evaluation of complete case study because MSCs is the multipotent cells which is able to differentiate into neuron cells and also provide new cells for the repair and remodeling of damaged tissues in the brain.
  3. We perform 3 times stem cell infusion via intreathecally in CP patients.

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and 1 year interval to monitor all the evoluations.

Scientific Articles:-
1. Wang et al. 2010 (Cardiology). Intracoronary Autologous CD34+ Stem Cell Therapy for intractable Angina
2. Klein et al. 2004 (The Heart Surgery Forum). Autologous Bone Marrow–Derived Stem Cell Therapy in Combination with TMLR.

If you have any queries related to stem cell therapy for Cornonary Arterial Disease then contact us without any hesitation on our contact numbers:-
Mb. No: +91-9891818024 , 9650699988
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