Cerebral palsy is a term used to describe a group of chronic conditions affecting body movements and muscle coordination. It is caused by damage to one or more specific areas of the brain, usually occurring during fetal development. Cerebral palsy affects body movement, muscle control, muscle coordination, muscle tone, reflex, posture and balance. It can also impact fine motor skills, gross motor skills and motor functioning. Secondary conditions can include seizures, epilepsy, apraxia, dysarthria or other communication disorders, eating problems, sensory impairments, mental retardation, learning disabilities, and/or behavioral disorders.

There are three main types of cerebral palsy:

• Spastic Cerebral Palsy (stiff and difficult movement)
• Athetoid Cerebral Palsy (involuntary and uncontrolled movement)
• Ataxic Cerebral Palsy (disturbed sense of balance and depth perception)
• Mixed Cerebral Palsy

There may be a combination of these types of cerebral palsy for any one person.

Stem cell Services for Cerebral Palsy:-
Currently available treatments for patients with cerebral palsy not curative. Stem cell treatment is the only treatment that has some good improvement in cerebral patient because when stem cells transplanted into CP patients then bone marrow derived stem cells concentrate (CD44+, CD31+, CD34+) have the capacity to regenerate the neurological damage area in the brain. The role of Mesenchymal Stem Cells (MSCs) is very crucial for brain disorder improvement because MSCs is the multipotent stem cells which are able to differentiate into neuron progenitor cells.

We provide best stem cell treatment for cerebral Palsy patients because we use autologous bone marrow derived stem cell concentrate (cocktail of all regenerative cells:-MSCs, HSCs, ESCs) and cultured Mesenchymal Stem cells derived from bone marrow and cord tissue both to make the improvement rate better in CP patients. Treatment with autologous bone marrow derived Mesenchymal stem cells (MSCs) provide multiple mechanisms including neuroprotection, immunomodulation and neuroregeneration.

Protocol Outline for Cerebral Palsy:-

1. We transplant “Bone marrow-derived stem cells concentrate (BMSCs)” via intrathecally/intravenously because it provides a rich growth factor (VEGF, TGF-ß, FGF) environment that may enhance the neuron formation. The iliac crest contains bone marrow which is a rich source of the regenerative cells including:-
   • Mesenchymal Stem Cells (MSCs, CD44+)):- MSCs which differentiate into many types of cells such as bone, cartilage, neuron and so more.
   • Hematopoietic Stem Cells (HSCs, CD34+)):- HSCs which differentiate into all types of blood cells and also provide enhance environment for MSCs activation.
   • Endothelial Stem Cells (ESCs, CD31+)):- ESCs which differentiate into all types of blood vessels.
   • Platelets: -
     1. To modulate the regeneration process
     2. Recruit bone marrow progenitor cells to loci of injury
     3. Provides adhesion site for stem cells
     4. Platelets fibrin provides migration highway at the site of injury
2. We also transplant cultured mesenchymal stem cells (MSCs) isolated from bone marrow or cord tissue after evaluation of complete case study because MSCs is the multipotent cells which is able to differentiate into neuron cells and also provide new cells for the repair and remodeling of damaged tissues in the brain.
3. We perform 3 times stem cell infusion via intreathecally in CP patients.

Cerebral Palsy Rehabilitation:-

Rehabilitation is the part of stem cell therapy. CP patients should have some kind of rehabilitation to help maximize their potential and to help teach techniques which make everyday life easier. Rehabilitation including physiotherapy provides enhanced environment to make stem cell more functional by helping the cell migrating and proliferation fast.

Key Points:-

1. Physical therapy may improve your ability to perform daily activities and make you feel better.
2. Occupational therapy may help you perform daily activities more easily-especially those involving your hands and arms, such as grooming, dressing, and eating. Assistive devices may be used to help you perform daily tasks.
3. Speech therapy may improve your communication skills if cerebral palsy symptoms are making speaking difficult.
4. Cognitive retraining may help improve cognitive impairment caused by cerebral palsy

Follow-up with patients:-

Our medical staff members will be in contact with patients to get complete follow-up at 1, 3, 6 months and I year interval.

Scientific Articles:-
1. F. Ramiraj et al. 2006, Medical Hypothesis and Research (The Journal for Innovative Ideas in Medical Research). Umbilical cord stem cell therapy for Cerebral Palsy.
2. Riordan et al. 2007, Journal of Translational Medicine. Cord blood in regenerative medicine: do we need immune suppression?

If you have any queries related to stem cell therapy for cerebral palsy then contact us without any hesitation on our contact numbers:-
Mb. No: +91-9760013103, +91- 9150171727
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